2. Signaling Pathways
  3. GPCR/G Protein
  4. Vasopressin Receptor
  5. V2 Receptor  Isoform
  6. V2 Receptor  Inhibitor

V2 Receptor  Inhibitor

V2 Receptor  Inhibitors (3):

Cat. No. Product Name Effect Purity
  • HY-165456
    AGN-190851
    		Inhibitor
    AGN-190851 is a potent and selective agonist of α2-adrenergic receptor (α2 adrenoceptor). AGN-190851 induces dose-dependent water diuresis in rats, and inhibits vasopressin V2 receptor in a species-dependent manner in vitro, thereby suppressing cAMP production. AGN-190851 enhances the contraction of porcine myometrium. AGN 190851 can be used in studies on renal diuretic mechanisms, pharmacology of α2-adrenergic receptor subtypes, and parturition.
  • HY-109133
    Pecavaptan
    		Inhibitor
    Pecavaptan, a chemical probe, is an orally active and dual antagonist of V1a/V2 receptor (Ki=0.5 nM and 0.6 nM for human, respectively). Pecavaptan promotes an increase in urine production, which reduces the associated symptoms of water retention and edema.
  • HY-165423
    DM-4111
    		Inhibitor
    DM-4111, one of the major monohydroxyl metabolites of Tolvaptan (HY-17000), is a potent vasopressin V2 receptor inhibitor. DM-4111 inhibits water reabsorption in the renal tubules, thereby promoting the excretion of electrolyte-free water. DM-4111 is promising for research of cardiovascular diseases.